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Oral Hormonal Acne Supplement

CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement

CLEARSTEM

Good internal approach for hormonal acne. Multi-targeted formula with promising ingredients, but limited clinical evidence on the complete formula.

$58 90 Capsules · $0.64/fl oz · Premium
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Ingredient Details
Free From: GlutenDairySoyArtificial ColorsArtificial Preservatives
Contains: 5-HTP (contraindicated with SSRIs)
Key Actives: DIM (Diindolylmethane)Vitamin B5 (Pantothenic Acid)Vitamin A (Retinyl Palmitate)L-Glutathione5-HTP
CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement by CLEARSTEM – 90 Capsules
100
0
0
Score for Acne-Prone Skin
Good
Skin Conditions
Why 82 score for Acne-Prone Skin ↓
Per-Condition Analysis

How CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement Performs Across 5 Skin Concerns

We evaluated CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement individually against 5 skin concerns — each with its own clinical reasoning, real user feedback, considerations, and usage guidance. Select a condition to explore its full analysis.

CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement for Acne-Prone Skin

Best Match
Good Ranked #1 of 5 conditions for this product
Verdict Good internal approach for hormonal acne. Multi-targeted formula with promising ingredients, but limited clinical evidence on the complete formula.

Expert Analysis

Receives a good rating (82/100) as an oral supplement targeting hormonal acne through multiple pathways including hormone regulation, liver support, stress management, and inflammation control. The formula combines DIM for estrogen metabolism, Vitamin B5 which has clinical backing showing 67% reduction in lesions in one RCT, and supporting ingredients like glutathione and milk thistle for detoxification. The company cites a 24-week clinical study showing efficacy, though this was conducted using the full CLEARSTEM routine rather than the supplement alone. User reviews are overwhelmingly positive with many reporting significant improvement in cystic and hormonal breakouts within 1-3 months. The multi-pronged approach addressing root causes rather than symptoms is scientifically logical, though individual ingredient concentrations are undisclosed. Best suited for adults with hormonally-driven acne, particularly those seeking a natural alternative to spironolactone or as an adjunct to topical treatments.

How to Use for Acne-Prone Skin

Take 2-3 capsules daily with a meal containing some fat for optimal absorption - never on an empty stomach due to digestive enzymes. If under 120-125 lbs, start with 2 capsules. If the 5-HTP causes drowsiness, take in evening to promote restful sleep. Allow 2-3 months minimum for visible results as the supplement works to rebalance internal systems. Combine with non-comedogenic skincare and identify dietary triggers for best outcomes. Discontinue if pregnant or planning pregnancy.

Important Considerations

  • 1 Contains 5-HTP which is contraindicated with SSRIs and mood medications - MINDBODYSKIN 2 version available without 5-HTP
  • 2 Requires 2-3 months of consistent use to see optimal results; some users report initial purging
  • 3 Not a replacement for topical acne treatments - works best as part of comprehensive routine
  • 4 Premium price point at $58/month may not be sustainable for all budgets
  • 5 Individual ingredient concentrations not disclosed, making it difficult to compare to standalone supplements

What Users Say for Acne-Prone Skin

523 Reviews
4.5 Avg Rating
85% Positive
Sources: AmazonClearstem WebsiteSalonCentricTikTokReddit

Users with hormonal and cystic acne report significant improvements, with many describing it as a game-changer after years of struggling with prescription treatments. Common praise includes reduced severity and frequency of hormonal breakouts, especially around menstruation. Multiple reviewers note they finally stopped getting new cystic pimples after just weeks of use, though scarring from previous breakouts remains. Some users report feeling more relaxed from the 5-HTP component, which can affect sleep if taken at wrong times. A small percentage experience initial breakouts or no improvement, with some noting the DIM can worsen acne in those with already low estrogen levels. The consistent theme is that it works best when combined with dietary changes and pore-safe skincare products.

Data collected: 2025-12-15
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CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement for Oily Skin

Good Ranked #2 of 5 conditions for this product
Verdict Good support for sebum regulation through internal pathways. B5 and DIM work together to balance oil production at hormonal level.

Expert Analysis

Achieves a good rating (78/100) for oily skin through its multi-pathway approach to sebum regulation from within. Vitamin B5 (pantothenic acid) has demonstrated ability to reduce sebum production through its role in coenzyme A metabolism, helping the body break down fats and oils more efficiently. DIM works on the hormonal level by potentially blocking androgen receptors that stimulate oil gland activity. Users consistently report noticeably less oily skin within 2-3 weeks of starting the supplement, with the face feeling less greasy throughout the day. However, this is an internal supplement rather than a topical mattifying product, so effects develop gradually and work systemically rather than providing immediate oil absorption. Score reflects the indirect but meaningful approach to oil control, best suited as a complement to topical oil-control products rather than a standalone solution for oily skin concerns.

How to Use for Oily Skin

Take 2-3 capsules daily with food for systemic support of oil regulation. Expect gradual improvement over 2-4 weeks as hormones begin to rebalance. Continue using appropriate topical products for oily skin including gentle foaming cleansers, lightweight moisturizers, and oil-control primers. The supplement addresses internal causes of excess oil while topicals manage surface concerns. Monitor oil levels in relation to menstrual cycle to track hormonal connection.

Important Considerations

  • 1 Effects on oil production are gradual and systemic - not immediate like topical mattifiers
  • 2 Works best for hormonally-driven excess oil rather than genetic predisposition to oily skin
  • 3 Should be combined with appropriate topical cleansers and lightweight moisturizers
  • 4 Some users report skin becoming less oily within 7-10 days, others need several weeks
  • 5 May be less effective if excess oil is not related to hormonal imbalance

What Users Say for Oily Skin

312 Reviews
4.3 Avg Rating
79% Positive
Sources: AmazonClearstem WebsiteSalonCentricBeauty Forums

Users with oily skin report noticeable reduction in facial shine and greasiness, particularly those whose oiliness is linked to hormonal fluctuations. Many describe not needing to blot as frequently throughout the day and that makeup stays put longer. The improvement in oil levels appears to correlate with overall acne improvement, suggesting the two are linked through the hormonal pathway. Some users note their skin felt less oily within the first week, while others needed a month to see changes. Those with combination skin report the most benefit in the T-zone area where hormonal oil production is highest. A minority report no significant change in oil levels despite improvements in acne.

Data collected: 2025-12-15
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CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement for Combination Skin

Good Ranked #3 of 5 conditions for this product
Verdict Good internal support for hormonal imbalances affecting combination skin. Helps regulate T-zone oil while supporting overall skin health.

Expert Analysis

Earns a good rating (76/100) for combination skin by addressing the hormonal component that often drives the oily T-zone characteristic of this skin type. The DIM and B5 combination works to regulate sebum in the naturally oilier areas while the overall anti-inflammatory and detoxification support benefits the entire face. Combination skin often results from hormonal fluctuations that cause inconsistent oil production across different facial zones, and this supplement targets that root imbalance. Users with combination skin report more balanced overall complexion with less dramatic differences between oily and dry areas. The turmeric and glutathione provide antioxidant support beneficial for overall skin health regardless of zone. However, the supplement cannot specifically target different facial areas, so topical products remain essential for addressing the varied needs of combination skin.

How to Use for Combination Skin

Take 2-3 capsules daily with food. Maintain a dual-approach topical routine using lighter products on the T-zone and more hydrating products on the cheeks and drier areas. The supplement works on internal balance while topicals address zone-specific surface needs. Track skin changes across your menstrual cycle to gauge hormonal impact. Allow 4-6 weeks to notice evening-out of skin balance.

Important Considerations

  • 1 Cannot differentially treat oily vs dry zones - works systemically on underlying causes
  • 2 Best combined with zone-specific topical routine using different products for T-zone vs cheeks
  • 3 Most effective for combination skin caused by hormonal fluctuations
  • 4 May help reduce severity of differences between oily and dry areas over time
  • 5 Still requires hydrating products for drier cheek areas

What Users Say for Combination Skin

198 Reviews
4.2 Avg Rating
76% Positive
Sources: AmazonClearstem WebsiteRedditSkincare Forums

Users with combination skin report feeling more balanced overall, with the oily T-zone becoming more manageable while not experiencing increased dryness in other areas. Many note that their skin feels more consistent throughout the month rather than dramatically more oily around their period. The anti-inflammatory ingredients help calm breakouts that typically occur in the oilier zones. Some reviewers mention needing to adjust their topical routine as their oil production decreased, using richer moisturizers on cheeks while maintaining lightweight products on the T-zone. Overall satisfaction is high among those whose combination skin is linked to hormonal fluctuations.

Data collected: 2025-12-15
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CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement for Hyperpigmentation

Good Ranked #4 of 5 conditions for this product
Verdict Good supporting role for post-inflammatory hyperpigmentation from acne. Glutathione and turmeric provide antioxidant brightening support.

Expert Analysis

Receives a good rating (74/100) as a secondary support for hyperpigmentation, particularly post-inflammatory marks from acne rather than melasma or sun damage. L-glutathione is a potent antioxidant with some evidence for brightening effects when taken orally, though absorption can be variable. Turmeric provides anti-inflammatory properties that may help prevent new dark marks from forming and support healing of existing ones. The vitamin A supports cell turnover which aids in fading discoloration over time. However, this supplement is primarily designed for acne treatment rather than hyperpigmentation correction, so it functions better as a complement to topical brightening actives like vitamin C, niacinamide, and retinoids rather than a standalone pigmentation treatment. Users report gradual fading of acne scars and marks, though this improvement takes months and works best when acne is controlled first.

How to Use for Hyperpigmentation

Take 2-3 capsules daily with food. Expect hyperpigmentation improvements to be gradual over 3-6 months as the supplement supports internal skin health and prevents new marks from forming. Combine with topical brightening serums containing vitamin C, niacinamide, or alpha arbutin for faster results. Always use SPF 30+ daily as sun exposure will worsen pigmentation. Focus first on acne control, as continued breakouts create new marks.

Important Considerations

  • 1 Designed primarily for acne - hyperpigmentation benefits are secondary
  • 2 Works best on post-inflammatory hyperpigmentation from acne, less effective for melasma or sun spots
  • 3 Should be combined with topical brightening treatments and diligent sun protection
  • 4 Fading of marks requires months of consistent use and acne control first
  • 5 Oral glutathione absorption varies between individuals

What Users Say for Hyperpigmentation

267 Reviews
4.1 Avg Rating
72% Positive
Sources: AmazonClearstem WebsiteRedditTikTok

Users note improvement in post-acne dark marks as a secondary benefit after their active acne cleared up. The consensus is that by stopping new breakouts, fewer new marks form, allowing existing pigmentation to fade naturally. Some specifically credit the glutathione for their skin appearing brighter overall. However, those with significant hyperpigmentation report needing additional topical treatments for satisfactory results. Users note that improvement in marks is gradual over 3-6 months rather than rapid. The turmeric and antioxidant blend appears to support overall skin clarity and evenness.

Data collected: 2025-12-15
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CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement for Sensitive Skin

Caution Ranked #5 of 5 conditions for this product
Verdict Use with caution. While anti-inflammatory ingredients help, 5-HTP and DIM can cause reactions. Introduce slowly and monitor.

Expert Analysis

Earns a cautious rating (58/100) for sensitive individuals due to the complex nature of oral supplements and their systemic effects. While the formula contains anti-inflammatory ingredients like turmeric and glutathione that theoretically support sensitive skin, the active compounds DIM and 5-HTP can cause reactions in some users. DIM affects hormone metabolism which can temporarily worsen skin conditions before improvement, and individuals with hormone sensitivities may experience adverse effects. 5-HTP affects serotonin pathways and can cause side effects including nausea, headaches, and sleep disturbances in sensitive individuals. Some users with sensitive skin report initial breakouts during an adjustment period. The lack of disclosed concentrations makes it difficult to predict individual responses. Those with known sensitivities to any ingredients or those on medications should consult healthcare providers before use.

How to Use for Sensitive Skin

Begin with 1 capsule daily for the first week to assess tolerance before increasing to full dose. Take with a substantial meal to minimize digestive upset. If 5-HTP causes issues, switch to MINDBODYSKIN 2 which omits this ingredient. Monitor for any adverse reactions including digestive discomfort, headaches, sleep changes, or skin worsening beyond normal purging. Consult healthcare provider if on any medications or have known sensitivities. Maintain a gentle topical routine during initial use.

Important Considerations

  • 1 Start with lower dose (1-2 capsules) to assess tolerance before increasing
  • 2 Contains 5-HTP which can cause nausea, headaches, or sleep changes in some people
  • 3 DIM can initially worsen skin before improving it during adjustment period
  • 4 Not recommended for those with estrogen-sensitive conditions without medical guidance
  • 5 Potential interactions with many medications - always consult healthcare provider
  • 6 If you experience adverse reactions, discontinue and consider the no-5-HTP version (MINDBODYSKIN 2)

What Users Say for Sensitive Skin

145 Reviews
3.8 Avg Rating
62% Positive
Sources: AmazonClearstem WebsiteRedditProduct Reviews

Reviews from sensitive individuals are mixed. Some report no issues and appreciate the anti-inflammatory benefits, while others experienced initial worsening of skin or digestive upset. A subset of users found the 5-HTP component affected their sleep or mood in unwanted ways, though others found it helpful for stress-related sensitivity. Those who experienced initial purging generally saw improvement after 2-3 weeks. Users with very sensitive systems often do better on the no-5-HTP version (MINDBODYSKIN 2) which has additional liver support instead. The turmeric and glutathione provide calming benefits once the body adjusts.

Data collected: 2025-12-15
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Frequently Asked Questions

Is CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement good for acne-prone skin?
CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement scores 82/100 (Good) for acne-prone skin. Good internal approach for hormonal acne. Multi-targeted formula with promising ingredients, but limited clinical evidence on the complete formula.
How do I use CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement for acne-prone skin?
Take 2-3 capsules daily with a meal containing some fat for optimal absorption - never on an empty stomach due to digestive enzymes. If under 120-125 lbs, start with 2 capsules. If the 5-HTP causes drowsiness, take in evening to promote restful sleep. Allow 2-3 months minimum for visible results as the supplement works to rebalance internal systems. Combine with non-comedogenic skincare and identify dietary triggers for best outcomes. Discontinue if pregnant or planning pregnancy.
Is CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement good for oily skin?
CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement scores 78/100 (Good) for oily skin. Good support for sebum regulation through internal pathways. B5 and DIM work together to balance oil production at hormonal level.
How do I use CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement for oily skin?
Take 2-3 capsules daily with food for systemic support of oil regulation. Expect gradual improvement over 2-4 weeks as hormones begin to rebalance. Continue using appropriate topical products for oily skin including gentle foaming cleansers, lightweight moisturizers, and oil-control primers. The supplement addresses internal causes of excess oil while topicals manage surface concerns. Monitor oil levels in relation to menstrual cycle to track hormonal connection.
Is CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement good for combination skin?
CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement scores 76/100 (Good) for combination skin. Good internal support for hormonal imbalances affecting combination skin. Helps regulate T-zone oil while supporting overall skin health.
How do I use CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement for combination skin?
Take 2-3 capsules daily with food. Maintain a dual-approach topical routine using lighter products on the T-zone and more hydrating products on the cheeks and drier areas. The supplement works on internal balance while topicals address zone-specific surface needs. Track skin changes across your menstrual cycle to gauge hormonal impact. Allow 4-6 weeks to notice evening-out of skin balance.
What are the key active ingredients in CLEARSTEM MINDBODYSKIN Hormonal Acne Supplement?
The key active ingredients are DIM (3,3'-Diindolylmethane), Vitamin B5 (Pantothenic Acid), Vitamin A (Retinyl Palmitate), 5-HTP (5-Hydroxytryptophan), L-Glutathione, Milk Thistle, Dandelion Root Extract, Turmeric Root Extract, Protease, Betaine Hydrochloride. Supports estrogen metabolism and hormone balance; may help regulate androgens that trigger sebum production

Key Active Ingredients

DIM (3,3'-Diindolylmethane)
Concentration: Not disclosed
Supports estrogen metabolism and hormone balance; may help regulate androgens that trigger sebum production
Vitamin B5 (Pantothenic Acid)
Concentration: Not disclosed
Clinically shown to reduce acne lesions by supporting lipid metabolism and reducing sebum production
Vitamin A (Retinyl Palmitate)
Concentration: Not disclosed
Supports cell turnover and keratolytic function to prevent clogged pores
5-HTP (5-Hydroxytryptophan)
Concentration: Not disclosed
Serotonin precursor that helps manage stress hormones and cortisol levels linked to acne
L-Glutathione
Concentration: Not disclosed
Master antioxidant that supports detoxification and may help brighten post-acne marks
Milk Thistle
Concentration: Proprietary Liver Blend
Liver support for detoxification and hormone metabolism
Dandelion Root Extract
Concentration: Proprietary Liver Blend
Digestive and liver support to help eliminate excess hormones
Turmeric Root Extract
Concentration: Not disclosed
Anti-inflammatory properties to help reduce acne-related inflammation
Protease
Concentration: Proprietary Digestive Blend
Digestive enzyme to support nutrient absorption
Betaine Hydrochloride
Concentration: Proprietary Digestive Blend
Supports stomach acid production for improved digestion and nutrient uptake

Full INCI Ingredients

Vitamin A (as Retinyl Palmitate)Pantothenic Acid (Vitamin B5) (as d-calcium Pantothenate)5-HTP (5-Hydroxytryptophan)DIM (3,3'-Diindolylmethane)Milk ThistleDandelion (Taraxacum officinale) ExtractL-GlutathioneTurmeric (Curcuma longa) Root ExtractProteaseBetaine Hydrochloride

Conflicts & Safety

SSRI medications - 5-HTP can interact with selective serotonin reuptake inhibitors and cause serotonin syndrome. Use MINDBODYSKIN 2 (no 5-HTP) version instead
MAO inhibitors - 5-HTP interaction risk
Pregnancy and breastfeeding - Not tested for safety during these periods
Blood thinning medications - Turmeric may enhance effects
Hormone-sensitive conditions - DIM affects estrogen metabolism; consult healthcare provider if you have hormone-sensitive conditions or low estrogen

Clinical Evidence

Level: Limited

The complete MINDBODYSKIN formula was tested in a 24-week clinical efficacy study with 30 participants showing improvement when used with full CLEARSTEM skincare routine - however this does not isolate supplement effects. Individual ingredients have varying evidence: Vitamin B5 has moderate clinical support from an RCT showing 67% reduction in acne lesions after 12 weeks. DIM has theoretical support for hormone modulation and antibiofilm activity against C. acnes in vitro, but no human clinical trials specifically for acne. 5-HTP has evidence for serotonin/stress pathway modulation but not specifically for skin conditions. Glutathione has limited oral bioavailability evidence. Overall, the formula combines plausible mechanisms but lacks robust independent clinical validation as a complete product.

Certifications

Gluten-FreeCruelty-FreeVegan CapsulesNon-GMOMade in USA
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