Niacinamide (Vitamin B3)

How Niacinamide Works

Niacinamide functions through multiple biochemical pathways simultaneously. It increases ceramide and fatty acid synthesis in the stratum corneum, directly strengthening barrier function. It inhibits melanosome transfer from melanocytes to keratinocytes, reducing melanin deposition and fading dark spots. It reduces sebaceous gland activity, decreasing sebum production by 30 to 50 percent at 10 percent concentration. It reduces the production of inflammatory cytokines, calming redness and irritation. It stimulates collagen synthesis and improves skin elasticity. This multi-mechanism action is why niacinamide benefits so many different skin concerns simultaneously.

Forms in Products

Evidence-Based Benefits

How to Use Niacinamide

Apply niacinamide serum after cleansing and before moisturizer, morning and evening. Start with once daily for the first week to assess tolerance, then increase to twice daily. Two to three drops for the full face is sufficient. Allow 30 to 60 seconds for absorption before the next step. Niacinamide works well with almost every other active including retinoids, vitamin C, AHAs, BHAs, and peptides. The old myth about vitamin C and niacinamide incompatibility has been thoroughly debunked by modern research.

• Start at 5 percent if you have sensitive skin, 10 percent for oily or acne-prone
• Can be used morning and evening without sensitization
• Layer before moisturizer, after water-based serums
• Compatible with retinoids, vitamin C, and acids
• Expect visible results in 4 to 8 weeks for oil control, 8 to 12 weeks for pigmentation

Who Benefits Most

Common Myths

Frequently Asked Questions