iS Clinical
iS Clinical (Innovative Skincare) was founded in 2002 by Bryan Johns and Alec Call in Los Angeles, with a mission to create pharmaceutical-grade skincare that bridges the gap between cosmetic products and medical treatments. The brand operates under the scientific guidance of a team of pharmacologists and physicians, and its products are exclusively available through licensed physicians, medical spas, and authorized skincare professionals. iS Clinical's formulations use bioavailable ingredients -- meaning actives are delivered in forms the skin can immediately utilize -- at concentrations that approach prescription-strength levels. The Active Serum, a multi-acid treatment combining glycolic acid, salicylic acid, and botanical extracts, has become the brand's most recognized product. iS Clinical maintains GMP (Good Manufacturing Practice) certification for its production facility.
Brand Philosophy
iS Clinical's philosophy is that skincare should be formulated to pharmaceutical standards with clinically proven botanicals and bioavailable actives. The brand does not compromise on ingredient quality or concentration to achieve a more marketable texture or price point. Distribution exclusively through medical professionals ensures products are used under appropriate guidance. The emphasis on bioavailability -- delivering actives in forms the skin can immediately use -- distinguishes iS Clinical from brands that use the same ingredients at lower bioavailable concentrations.
Consumers seeking the highest tier of clinical skincare, typically purchased through a dermatologist or medical spa. Best for those with specific skin concerns requiring professional-strength actives, and anyone transitioning from prescription treatments to maintenance skincare.
- Active Serum -- multi-acid professional-grade treatment
- Pharmaceutical-grade formulations with GMP certification
- Exclusively sold through licensed medical professionals
- Bioavailable ingredient delivery technology
- Pharmacologist and physician-guided development
- Glycerin
- Hyaluronic Acid
- Mixed Fruit Acid Complex
- Copper Tripeptide-1 (GHK-Cu)
- Superoxide Dismutase (SOD)
iS Clinical at a Glance
Strongest Categories
iS Clinical performs best in: Exfoliant (1 product, avg 88/100); Cleanser (1 product, avg 83/100); Anti-Aging Treatment (1 product, avg 78/100).
Best Conditions Served
Across all products, iS Clinical scores highest for: Dull/Uneven Texture (avg 90/100); Aging/Mature Skin (avg 89/100); Combination Skin (avg 88/100). If your primary concern is one of these conditions, iS Clinical products are particularly worth considering.
Certifications
Common certifications include Paraben-Free, Developed with dermatologists and pharmacologists, Professional-grade pharmaceutical skincare, Dermatologist Approved, Phthalate-Free, Sulfate-Free.
Best iS Clinical by Skin Condition
The highest-scoring iS Clinical product for each condition we evaluate.
iS Clinical Youth Intensive Creme
iS Clinical Active Serum
iS Clinical Warming Honey Cleanser
iS Clinical Active Serum
iS Clinical Warming Honey Cleanser
iS Clinical Youth Intensive Creme
iS Clinical Active Serum
iS Clinical Warming Honey Cleanser
iS Clinical Active Serum
iS Clinical Warming Honey Cleanser
All iS Clinical Products (3)
iS Clinical Active Serum
iS Clinical Youth Intensive Creme