Brand

E45

E45 is a British skincare brand with pharmaceutical heritage dating back to 1952, originally developed as a prescription emollient for dry skin conditions. The brand's E45 Moisturising Cream became a UK pharmacy staple, recommended by dermatologists and GPs for eczema, dry skin, and other dermatological conditions. E45 is now owned by Karo Healthcare and remains one of the most trusted pharmacy skincare brands in the UK and Commonwealth countries.

Mid-Range Dermatologist Recommended Est. 1952 United Kingdom Karo Healthcare

1 Products

10 Evaluations

81 Avg Score

1 Categories

Best E45 product by condition:

Dry 91 Oily 72 Combo 80 Acne 76 Sensitive 92 Aging 78

Brand Philosophy

E45 delivers pharmaceutical-grade moisturizing and barrier protection for clinically dry and dermatologically compromised skin, maintaining the same trusted formulations that earned GP and dermatologist recommendations for decades.

Who It's For

Those with clinically dry or eczema-prone skin seeking pharmaceutical-grade emollients trusted by UK healthcare professionals.

Known For

UK pharmacy staple since 1952
GP and dermatologist recommended
E45 Moisturising Cream for dry/eczema skin
Pharmaceutical-grade emollient heritage
Trusted across UK and Commonwealth

Signature Ingredients

Panthenol (Pro-Vitamin B5)
Squalane
Glycerin
Oat Extract (Avena Sativa Kernel Flour and Oil)
Lactic Acid

E45 at a Glance

Strongest Categories

E45 performs best in: Moisturizer (1 product, avg 81/100).

Best Conditions Served

Across all products, E45 scores highest for: Eczema-Prone Skin (avg 93/100); Sensitive Skin (avg 92/100); Dry/Dehydrated Skin (avg 91/100). If your primary concern is one of these conditions, E45 products are particularly worth considering.

Certifications

Common certifications include Dermatologically Tested, Fragrance-Free, Suitable for Eczema-Prone Skin, Safe for Newborns and Children, 90%+ Natural Origin Ingredients, Hypoallergenic.

Best E45 by Skin Condition

The highest-scoring E45 product for each condition we evaluate.

Dry/Dehydrated

All E45 Products (1)

Sort:

Barrier Repair Cream High

Moisturizer

E45 Cica Soothe and Repair Cream

Frequently Asked Questions about E45

What is the best E45 product?

Based on our scoring, E45 Cica Soothe and Repair Cream is the highest-rated E45 product with a score of 93/100 for eczema-prone skin. Best-in-class eczema support. Clinically-proven barrier repair with oat extract validates decades of E45 expertise.

Is E45 worth the price?

E45 products are positioned at the mid-range tier with an average score of 81/100 across 1 evaluated products. This represents strong value, with several products matching or exceeding more expensive alternatives.

What skin type is E45 best for?

E45 scores highest for eczema-prone skin, with an average score of 93/100 across relevant products. They also perform well for sensitive skin and dry/dehydrated skin. Check condition-specific scores for the product you are considering.

Every E45 product above has been scored individually for each relevant skin condition. Click any product to see its full evaluation, ingredient analysis, and usage guidance for your specific concern.